Biography of Bill Gates

Biography of Bill Gates Free Online Research Papers William (Bill) H. Gates III is co-founder, chairman and chief executive officer of Microsoft Corporation, the worlds leading provider of software for personal computers. Bill Gates was born on October 28, 1955. He and his two sisters grew up in Seattle. Their father, William H. Gates II, is a Seattle attorney. Mary Gates, their late mother, was a schoolteacher, University of Washington regent and chairwoman of United Way International. Gates attended public elementary school before moving on to the private Lakeside School in North Seattle. It was at Lakeside that Gates began his career in personal computer software, programming computers at age 13. In 1973, Gates entered Harvard University as a freshman, where he lived down the hall from Steve Ballmer, who is now Microsofts president. While at Harvard, Gates developed a version of the programming language BASIC for the first microcomputer the MITS Altair. BASIC was first developed by John Kemeny and Thomas Kurtz at Dartmouth College in the mid-1960s. In his junior year, Gates dropped out of Harvard to devote his energies full-time to Microsoft, a company he had started in 1975 with his boyhood friend Paul Allen. Guided by a belief that the personal computer would be a valuable tool on every office desktop and in every home, they began developing software for personal computers. Gates foresight and vision regarding personal computing have been central to the success of Microsoft and the software industry. Gates is actively involved in key management and strategic decisions at Microsoft, and plays an important role in the technical development of new products. Much of his time is devoted to meeting with customers and staying in contact with Microsoft employees around the world through e-mail. Under Gates leadership, Microsofts mission is continuously to advance and improve software technology, and to make it easier, more cost-effective and more enjoyable for people to use computers. The company is committed to a long-term view, which is reflected in its investment of some $2.6 billion for research and development during the current fiscal year. In 1995 Gates wrote The Road Ahead, his vision of where information technology will take society. Co-authored by Nathan Myhrvold, Microsofts chief technology officer, and Peter Rinearson, The Road Ahead held the No. 1 spot on the New York Times bestseller list for seven weeks, and remained on the list for a total of 18 weeks. Published in more than 20 countries, the book sold more than 400,000 copies in China alone. In 1996, while strategically redeploying Microsoft to take advantage of the emerging opportunities created by the Internet, Gates thoroughly revised The Road Ahead to reflect his view that interactive networks are a major milestone in human communication. The paperback second edition also has become a bestseller. Gates is donating his proceeds from the book to a non-profit fund that supports teachers worldwide who are incorporating computers into their classrooms. In addition to his passion for computers, Gates is interested in biotechnology. He sits on the board of the ICOS Corporation and is a shareholder in Chiroscience Group of the United Kingdom and its wholly owned subsidiary, Chiroscience RD Inc. (formerly Darwin Molecular) of Bothell, Wash. He also founded Corbis Corporation, which is developing one of the largest resources of visual information in the world a comprehensive digital archive of art and photography from public and private collections around the globe. Gates also has invested with cellular telephone pioneer Craig McCaw in Teledesic, a company that is working on an ambitious plan to launch hundreds of low-orbit satellites around the Earth to provide a worldwide two-way broadband telecommunications service. In the dozen years since Microsoft went public, Gates has donated more than $800 million to charities, including $200 million to the Gates Library Foundation to help libraries in North America take advantage of new technologies and the Information Age. In 1994 Gates established the William H. Gates Foundation, which supports a variety of initiatives of particular interest to Gates and his family. The focus of Gates philanthropy is in four areas: education; world public health and population; non-profit, civic and arts organizations; and Puget Sound-area capital campaigns. Bill and Melinda French Gates were married on January 1, 1994. They have one child, Jennifer Katharine Gates, who was born in 1996. Research Papers on Biography of Bill GatesThe Project Managment Office SystemRiordan Manufacturing Production PlanOpen Architechture a white paperNever Been Kicked Out of a Place This NiceBionic Assembly System: A New Concept of SelfPersonal Experience with Teen PregnancyMarketing of Lifeboy Soap A Unilever ProductAnalysis of Ebay Expanding into AsiaDefinition of Export QuotasTwilight of the UAW

Swing Kids essays

Swing Kids essays Living in Hamburg, Germany during the period of the Adolph Hitler regime was not easy for anyone. The WWII movie, Swing Kids, followed the lives of coming of age teenagers who were faced with situations that questioned their integrity. These particular boys Peter, Thomas, and Avrid were best friends and were determined to withstand their friendship through trying times in Nazi Germany. What set these boys apart from all their peers, who were joining Hitlers Youth Brigade at the time, were that they rebelled from the Nazi movement, by embracing the forbidden pastimes of British fashion, Harlem Slang, American movies, and Swing music. Most importantly, Swing Kids portrayed each young mans struggle to choose between friendship, family and freedom as the Nazi movement swept through Germany. Swing heil, swing heil as the swing kids would often say as they greeted each other. The main basis behind the swing movement was that they strictly opposed the fascist oppression that was being caused by the infamous Adolph Hitler. But the three particular young men in this movie, Peter, Thomas and Avrid, were not as vocal about their opposition with the Hitler youth brigade. Instead they would disguise as supports of Hitler by day and by night they were full-fledged swing kids, who attended swing dance clubs with their fellow swing kids. Peter was very defiant, Thomas was very emotionally weak, and Avrid was the intelligent and very hypercritical character. Life was going very well, the boys attended school to become engineers, they had a strong friendship, and most importantly they had swing music, which played a very big part in their lives. It was not until a practical joke, that every took a bad turn. After an attempt to steal a radio from a local bakery, Peter gets caught and luckily Thomas gets away. After being taken into custody by the Gestapo, Peter is punished for his actions. In hopes of giving ...

The changing role of women in Japanese history Research Paper - 1

The changing role of women in Japanese history - Research Paper Example Koyama (pp.56) indicates that the Japanese woman is no longer the pale skinned, quiet and submissive woman. Majority of the women in the Japanese society today lack the nature of being too accommodating and obedient to the impositions on them. Studies indicate that these women are on the verge of making own decisions despite the forces behind their oppositions. In the previous centuries, specifically the Edo period, women were an oppressed lot in relation to the Confucian thoughts. Inheritance of property, land ownership or taking part in politics was forbidden in the Japanese society. Women were not allowed to attend schools for fear of their ability to rule the society. In this society, women were allowed to read books in ‘kana’ so that they would not have a leeway to success. Over the years the women in the Japanese culture were not allowed to take part in the war. However, that role is slowly changing and a number of women have come up to challenge that perception. Among the notable examples include, Nakano Takeko from the Aizu clan of the Japanese. This woman is remembered for her ability to lead the women’s army at a time when women were forbidden to take part in any form of war. The driving force towards Nakano taking part in the war was to instill brevity among women that would assist them in the absence of the males in the society. Nakano set an example to many other women by undergoing training in martial arts and even setting up a training school.

Literature Review Essay Example | Topics and Well Written Essays - 5000 words

Literature Review - Essay Example . Consumers are attracted through advertising and promotions. The first impression that a consumer attains through advertising influences his purchasing decisions. To create a positive impression, companies try to create a distinctive brand image for their products. The strategy is to utilize celebrities as endorsers in marketing campaign and it is growing increasingly popular. Companies usually use talent – movie actors, models, athletes or famous people for endorsement (Bergestrà ¶m & Skà ¤rfstad, 2004). Not just the large firms, even smaller companies with limited budget use sports and athletes to promote their products. Companies all over the world spend millions ever year to acquire celebrities to endorse their product. It hence become important to determine why companies choose celebrities to endorse their products, on what basis they select the celebrities and whether they get the expected returns from such endorsement. This proposal will briefly discuss the background with definition of ‘celebrities’ and after research justification and outlining the questions, based on the literature available, it will form a framework for research. A celebrity is defined as "an individual who is known to the public (i.e., actor, sports figure, entertainer, etc.) for his or her achievements in areas other than that of the product class endorsed" (cf., Friedman and Friedman 1979 cited by Kamins, Brand, Hoeke & Moe, 1989). The use of celebrities for product endorsement was on the rise in the late 1970s. While it was estimated that 15 percent of prime time television commercials featured celebrities in 1975, by 1978 it was reported to be over 20 percent (Kamins, Brand, Hoeke & Moe, 1989). Kamins et al (1989) conducted a study to determine the impact on advertising effectiveness and credibility based one two-sided versus one-sided celebrity endorsements.

FOIA and Privatization of Government Article Example | Topics and Well Written Essays - 500 words

FOIA and Privatization of Government - Article Example There should a difference in the way of privatizing the traditional governmental services and the private corporation using public funding for non-traditional services because the two are very distinct in the manner of disseminating their duties. The traditional government needs more strict rules in guiding against the events of FWAC because their services affect the entire public and a small flaw in them could lead to the collapse of the whole institution. On the other hand, the private corporations require observance as well but to a smaller extent based on the nature of the population they serve. The examples of FWAC in private corporations and nonprofit corporations that were not subjected to FOIA, but may have been prevented by FOIA include misappropriation of funds by the management, tax evasion, stealing the properties of the firms. Also, giving and taking of bribes, the incorrect use of resources by wasting them and offering favors to the friend and family members. All these FWAC have been prevented by the availability of checks by the FOIA board that has scared those in charge of practicing such vices. The incapacity of the FOIA legislation to force the private corporation to provide information when needed the contracting government agency can mitigate this by setting in the contract the terms that the information regarding the use of public funds should be disclosed to the public. The condition will enable the provision of data concerning the use of the public funds. The private corporations need the support of the government and, therefore, they will be forced to comply and provide the information otherwise they will not have such chances. The issue of concern based on the experience is the style of the provision of the information needed by the public by the FOIA. The fee charged should be reviewed from the set minimum of 15 dollars to as low as 7 dollars.

N. Fowleri Diagnosis, Treatment and Prevention

N. Fowleri Diagnosis, Treatment and Prevention Historical Aspect: Naegleria Fowleri (N. Fowleri ) is a free living, thermophilic protozoan that is a human specific pathogen that attacks the central nervous system. It can be found in contaminated freshwater sources. It enters through the nose and travels to the brain causing primary amoebic meningoencephalitis1. It was first observed in 1899 and later named after Dr. M. Fowler, who observed the first reported fatal cases of acute pyogenic meningitis in Australia in 19652. While these infections have been identified as early as the 19th century it is challenging to identify because it mimics many of the symptoms of bacterial meningitis[1]. Primary amoebic meningoencephalitis (PAM) is a necrotizing and hemorrhagic meningoencephalitis3. The symptoms begin 1-9 days after the onset of infection these symptoms include fever, nausea, headache and vomiting. The initial symptoms mimic those of bacterial meningitis, the later symptoms are unique to this disease. Later symptoms include neck stiffness, hallucinations, seizures, an inability to focus, lack of balance and eventually coma and death. The mortality rate for this disease is 95%. The disease progresses quickly and leads to death within 12 days of the initial infection1. While this infection has a high mortality rate, it is very rare. There have been 300 reported cases of PAM worldwide in the last 40 years4. It is important to note that this conditioned is often misdiagnosed so these numbers are estimates. In the United States there have been 138 cases in the last 50 years1. This infection was once a condition that plagued developing countries but the incidence is spreading all over the world. Researchers suspect that the increased temperatures due to global warming, increased use of public water sources due to scarcity and an overall increase in aquatic recreational activities are to blame3,18. While swimming and other aquatic recreational activities help proliferate this disease so do rituals. Aga Khan University in Pakistan noticed an increased number of deaths caused by PAM in young males that had no history of swimming, but were devout Muslims. Those who practice this faith pray five times a day and before every prayer, they perform ablution, ablution is the washing of the hands, face, ears, nose, mouth, arms and feet. While cleansing the nose, water is forced up the nose putting individuals performing this practice with inadequately purified water at a greater risk for PAM3. Religious festivals like the Kumbh Mela where Hindus gather and swim in the Ganges river put those who participate at risk of developing diseases like PAM caused by N. Fowleri 3. In addition to religious practices, therapeutic interventions like the Neti pot increase the risk of PAM. Nasal irrigation systems like the Neti pot work to relieve the symptoms of sinusitis and cold. It works by removing debris and mucus from the nasal passages. The recommendation is that the water should be boiled or mixed with a non-ionized sodium chloride. Basic structure: N. Fowleri are a part of the free living amoeba that cause infections in the central nervous system. Some of the other protists are Acanthamoeba spp and Balamuthia mandrillas. Naegleria fowleri have been classified by modern techniques which analyze morphology, biochemical pathway and molecular phylogeny2. The modern approach classifies N. Fowleri as a part of the super group Excavata, in the group Heterolobosea and a part of the family Vahlkampfiidae. Although the genome for N. Fowleri is not yet completed there are some studies producing information about its molecular and genetic characteristics. N. Fowleri s genus includes more than 40 species, but N. Fowleri is the only one that is known to cause disease in humans. De Jonckheere created the most popular identification system for N. Fowleri . The identification system uses genetic markers like internal transcribed spacers (ITS1) and 5.8S rDNA 2. This identification system revealed at least 8 different genotypes. The genotypes are dispersed among different continents America (I,II,III), Europe (III,IV,V,VI,VIII), Oceania (V), and Asia (II,III). Of the eight genotypes only four have been found in humans, types 1-42. Naegleria are a part of the group heteroloboseans that have a three-phased lifecycle. They are first amoeba, then flagellate and lastly cyst formation5. N. Fowleri reproduces in the amoeba form via binary fission to produce the cyst and the flagellate forms. The entire cell cycle is 8 hours, N. Fowleri spends 28 minutes in M phase, 180 minutes in G1, 183 minutes in S phase, and 90 minutes in G22. In the amoeba form, the trophozoite ranges in size from 15-25 Â µm. Trophozoites also have cytoplasmic projections called food cups which allow phagocytosis of bacteria, yeast, erythrocytes and cellular waste. Trophozoites are the form of the amoeba that can feed and divide, they are also the form that enter the human host6.Trophozoites will transition into the flagellate stage after being exposed to a saline solution2. The flagellates cannot feed or divide, the transition also involves a change in shape from pleomorphic to pear shaped with a pair of flagella. The flagella have the typical 9+2 structure and are surrounded by a cytoplasmic membrane. The 9+2 flagella structure describes the cross- sectional arrangement of microtubules that make up the flagella. There are nine doublet outer tubules and two central singlet tubules7. The cyst form is resistant to most disinfection. The cyst formation is spherical, smooth, double walled and refractive. They measure about 20Â µm. The material of the cyst wall is synthesized and packaged by the rough endoplasmic reticulum2. Route of Transmission: N. Fowleri is a thermophilic amoeba, its optimal temperature ranges from 1150 to 1220 F. N. Fowleri can typically be found in warm freshwater like lakes and rivers, warm water from industrial parks, or inadequately chemically treated water, other warm water sources like water heaters and soil. In their natural environment N.Fowleri phagocytize cyanobacteria and eubacteria to regulate levels. Samples from the lakes of the southern United States reveal that N. Fowleri introphozoite formis present during the summer. During the winter months N. Fowleri in cyst form survive in freshwater sources, but no form of N. Fowleri can withstand freezing temperatures1 . Most cases of PAM are caused by swimming in warm freshwater, from drinking water, recreational activities, ritual abulation and sinus irrigation systems1. Infection occurs when water containing N. Fowleri gets into the nose. The amoeba enters the nose and travels along the olfactory nerve, through a bony plate in the skull called the cribriform plate3. Once it reaches the brain it causes meningoencephalitis, cerebral edema and results in herniation. The olfactory bulbs and orbitofrontal cortices become necrotic and hemorrhagic. The data on both humans and mice support the conclusion that death is ultimately caused by increased intracranial pressure and herniation3. Swimming in water containing N. Fowleri increases the risk for PAM but age and sex are also risk factors. From the 1962- 2015 there have been 138 reported cases of PAM in the United States, 114 of the cases have been children around the age of 12. Nearly 75% of the infections have affected males1. Certain behaviors are associated with an increased risk of infection, those infected individuals reported participating in water related activities like swimming, diving and head dunking1. Although N. Fowleri can be transmitted through water it cannot be transmitted through aerosols or droplets, or via person to person contact. N. Fowleri can be found in other organs of the body, such as the heart, lung, spleen and thyroid1. Pathogenesis: N. Fowleri enter the human host through the nose which provides access to the brain. Within eight hours of infection N. Fowleri is present in the mucus layer of the olfactory epithelium. Within 24 hours N. Fowleri are in the olfactory bulb and present in the cribriform plate. By 96 hours neutrophil polymorphs cause a severe inflammatory response in the olfactory bulb which leads to brain tissue damage3. Contact dependent mechanisms are N. Fowleri mediated pathogenic processes. The primary mechanism of pathogenesis in N. Fowleri is adhesion. Adhesion allows for movement and chemotaxis in the nasal mucosa and assists N. Fowleri with disease progression. Adhesins are expressed on the surface of N. Fowleri, the adhesins are integrin like proteins surrounded by adhesion like structures. Fibronectin binding protein, protein kinase C and NFa1 are important to interrupting the host mediated cytotoxicity3. In an experiment testing cytopathicity of N. Fowleri, a culture would bind to Fibronectin and in the presence protein kinase C the ability of the amoeba to adhere increased8. N. Fowleri also produces Reactive Oxygen Species (ROS) which damage the host cell. Following cell damage, N. Fowleri uses phagocytosis and amoebastomes to assist N. Fowleri in breaking down and consuming the cells through a sucker structure on its surface. These processes are mediated via actin and involve the polymer ization of monomeric G-actin and filamentous F-actin. Studies have found that a membrane protein Mp2CL5 may also play a role in pathogenicity, without this protein N.Fowleri are nonpathogenic3 .This protein is suspected to aid in pathogenicity by navigating the environment, and movement toward food sources9. In addition to contact dependent mechanisms of pathogenicity, N.Fowleri also utilizes contact independent mechanisms. N-PFP is a cytolytic pore forming protein that depolarizes the cell membrane and decreases the integrity. Naegleriapores A and B are pore forming polypeptides that are very similar in structure and function. Both are antimicrobial and cytolytic polypeptides3. The enzymes phospholipase A, A 2 and C are present in patients with PAM. Phospholipases are responsible for the demyelination of white matter. Sphingomyelinase, neuroaminidase, elastase and proteolytic enzymes are responsible for demyelinating nerve tissue. N. Fowleri are hemolytic due to the heat shock protein 70 which is unaffected by salt concentrations, chelating agents, pH and temperature extremes3,10. This protein is present in the cytoplasm, pseudopodia and phagocytic food cups. There are many other factors associated with the pathogenicity of N. Fowleri and others that are suspected to have an effect on t he pathogenicity. On the onset of infection the hosts innate immune system attempts to reduce the pathogens cytotoxicity. During the early infection the body releases mucin which surrounds the N.Fowleri trophozoites to prevent cytotoxicity. In the later infection eosinophils and neutrophils surround the N. Fowleri cells to prevent cytotoxicity. Inflammation increases over time, although there are not many cells that penetrate the host epithelium. The inflammation and polymorph nuclear cells from the host response damage cerebral tissue2 . Diagnosis, Treatment, Prevention: Diagnosis of N. Fowleri is heavily dependent on laboratory techniques. The most effective way to diagnose N. Fowleri requires cerebrospinal fluid (csf) which is conducted while the patient is living and brain biopsy which is conducted post-mortem11. Different laboratory tests are utilized to analyze the specimen. When PAM is suspected, samples can be wet mounted and placed under a microscope to identify trophozoites12. Polymerase chain reaction is a method that can be used to amplify DNA, to identify the presence of N. Fowleri DNA in a sample11. Another laboratory technique involves antigens that were developed from mouse monoclonal antibodies (mAbs) against N. Fowleri . When indirect immunofluorescence assays are used mAbs react to N.Fowleri from specific geographic regions13. The infection due to PAM progresses quickly and as previously stated, mimics symptoms of bacterial meningitis. Even with the advances in laboratory diagnostics most cases are diagnosed post mortem making effective treatment elusive. One successful case study provides an example of effective diagnosis and treatment of this condition. On July 13, 2013, a 12 year-old girl presented to Arkansas Childrens Hospital vomiting, having trouble holding up her head and was unable to open her eyes. A few days prior to hospitalization the patient had been playing in a local water park. During her hospitalization she experienced hallucinations, and thirst. A spinal tap was performed which ruled out bacterial meningitis. The laboratory identified N. Fowleri trophozoites in the patients cerebrospinal fluid. After determining the infection was PAM caused by N. Fowleri, physicians initially treated the patient with antibiotics and antifungals like Amphotericin B, Rifampin, Fluconazole, Dexamethasone an d Azithromycin .None of these treatments improved the condition of the patient. The hospital petitioned the Center for Disease Control (CDC) to allow the use of a new experimental drug available for the treatment of N.Fowleri14. The drug Miltesfosine was given 36 hours after the initial diagnosis, physicians also lowered the patients body temperature to 93.2 F0 to reduce cerebral edema and intracranial pressure. After 18 days in the ICU there was no N. Fowleri found in her system. The patient experienced a full but gradual recovery over the next fifty five days. After seven days the patient was able to write her name, in fourteen days she was able to speak in one and two syllable words. She also underwent both speech and physical therapy14. This patient is one of the three known survivors of PAM. While the virulence factors and the degree of recovery that surround the other two cases of survival are unknown. The prompt diagnosis, treatment with Miltesfosine within thirty six hours and maintaining a low body temperature for this patient played significant roles in effectively treating this infection14. Although the first case of N. Fowleri was over 50 years ago, the mortality rate for this disease continues to increase due to water scarcity which increases use of water from public sources. As previously stated this condition is either diagnosed post mortem or misdiagnosed. The development of a standard microbial treatment will aid in the reduction of high mortality rates14. In the three cases of survival the patients were all intially treated with amphotericin B, rifampcin, fluconazole, dexamethasone and phenytoin during the first week of infection15. In 1969 a patient survived PAM with the successful treatment of amphotericin B. The patient in 2013 was initially treated with amphotericin B and it was ineffective. Miltesfosine effectively treated this patients PAM14. Other drugs with the potential to treat PAM have been tested, and some have been proven effective while others have not. Clotrimazole a drug that has been used as an antifungal had potential to treat PAM but under further study was deemed ineffective16. In developing countries like Pakistan where water is in short supply and ablution is common practice the danger of becoming infected with N. Fowleri is greatly increased. Water sources in these countries include wells or water storage tanks which are often contaminated with N. Fowleri 17. In order to prevent infection the World Health Organization (WHO) encourages that water storage units and wells be regularly tested to ensure proper disinfection. Public health organizations have also encouraged the use of nose clips while swimming in lakes and other freshwater sources, and boiling water that is used for ablution17. Chlorine disinfection regimens prevent against most pathogens in drinking water systems however free living amoeba like N. Fowleri survive most disinfection. The cyst form of N. Fowleri is resistant to most disinfection and are associated with biofilm that can build up in drinking water systems. N. Fowleri have been isolated in drinking water systems in Australia, the United States and Pakistan, in both Australia and the United States they maintain chlorine levels of 0.5mg/L at all times in the drinking water18.To test the amount of chlorine needed to eliminate N. Fowleri, researchers conducted an experiment using two separate sites, a pre re-chlorination site and a post re-chlorination site, both sites were monitored before and after re-chlorination for a year. The results were that after chlorination of greater than 1mg/L at each site, in the post re-chlorination site the amoeba were gone within 60 days. The pre re-chlorination site would have seasonal flares of N.Fowleri but the c hlorine levels eliminated the protozoan and prevented further spread. Overall chlorine levels above 1mg/L result in the elimination of N.Fowleri in drinking water systems18. Summary of current areas of research notes: N. Fowleri is a rare pathogen that was discovered over fifty years ago. Since its discovery still not much is known about this pathogen. Future research into this pathogen will focus on patient complaint diagnosis and treatment, expanding the drugs that are used, biomarkers, and drug targets. In order to determine whether the patient has contracted PAM due to N.Fowleri the patients csf is tested and if the test is negative for bacterial cultures and the patient has a history of swimming or other aquatic activities, then the patient tests positive for N.Fowleri. Extracting csf can increase the pressure in the patients brain and lead to herniation of the brain. Because N. Fowleri travels to the brain via the nasal passage, the proposed route of diagnosis is collecting a nasal sample. Research confirms that N.Fowleri can be collected in both csf and nasal cultures3. Drugs administered through the nasal cavity, through the transcribial route would be delivered across the cribifrom plate to the inferior portion of the frontal lobe. This is the site where N. Fowleri attacks and spreads to the central nervous system. Drugs like amphotericin B do not decrease the minimum inhibitory concentration (mic) when administered intravenously. By potentially administering the drug transcribialy, the drug passes the blood barrier which would allow the drug to be more potent, trail the route of N.Fowleri, attack the site of infection, allow the lethal dose of drug to achieve the mic without venous drainage, and lastly to avoid symptoms of intravenous drug administration 15. There are clinically approved drugs that have promising amoebicidal effects. These drugs interrupt the mechanisms and processes of the amoeba. Digoxin and proyclidine both exhibit amoebicidal properties. Digoxin treats atrial fibrillation and heart rhythm disorder by helping the heart beat stronger and with more rhythm19. Proyclidine is used to treat Parkinsons and other diseases that cause involuntary muscle movement20. In order for further testing of the amoebicidal effects of these drugs to continue to be studied more drugs that have the potential to be amoebicidal must be identified and screened for tests to go from in vitro testing to in vivo testing. There has not been a lot of emphasis on finding drugs that treat N. Fowleri because the condition is rare and affects populations in the developing world. Biomarkers for PAM have been challenging to identify because little is known about N. Fowleris pathophysiology. Mass spectrometry, NMR and other tools of analysis are being utilized to identify biomarkers. Researchers are also making biochemical profiles of individuals in populations that contracted the disease against those who did not. These profiles will include information on the individuals age, gender, ethnicity and factors that predispose them to this condition3. This condition is rare and because of its rarity has been studied infrequently. With limited time and resources N.Fowleri is funded and studied less frequently than conditions that affect larger populations like Malaria or the Zika virus. The range of drugs used to treat patients with PAM is severely limited, researchers are developing drugs that would inhibit different processes of N.Fowleri. The drug pathways are hydrolytic enzymes that invade the host cells, glycocytic enzymes that are expressed differently by the pathogen, thiol based redox metabolism pathway, oxidative stress pathway, trypanothione pathways, and encystation and excystation pathways3. Bibliography 1. Naegleria fowleri- primary amebic meningoencephalitis (PAM) amebic encephalitis. Centers for Disease Control and Prevention Web site. =. Updated December 2015. Accessed January, 2017. 2. Martinez-Castillo M, Cardenas-Zuniga R, Coronado-Velazquez D, Debnath A, Serrano-Luna J, Shibayama M. Naegleria fowleri after 50 years: Is it a neglected pathogen? J Med Microbiol. 2016. doi: 10.1099/jmm.0.000303 [doi]. 3. Siddiqui R, Ali IKM, Cope JR, Khan NA. Biology and pathogenesis of naegleria fowleri. Acta Trop. 2016;164:375-394. doi: http://dx.doi.org/10.1016/j.actatropica.2016.09.009. 4. Coupat-Goutaland B, RÃ ©goudis E, Besseyrias M, et al. Population Structure in Naegleria fowleri as Revealed by Microsatellite Markers. Chiang T-Y, ed. PLoS ONE. 2016;11(4):e0152434. doi:10.1371/journal.pone.0152434. 5. The genome of naegleria gruberi illuminates early eukaryotic versatility. Cell. (- 5):- 631. doi: 10.1016/j.cell.2010.01.032. 6. Marciano-Cabral F, Cabral GA. The immune response to naegleria fowleri amebae and pathogenesis of infection. FEMS Immunology Medical Microbiology. 2007;51(2):243-259. doi: 10.1111/j.1574-695X.2007.00332.x. 7. Lodish H, Berk A, Zipursky SL, et al. Molecular Cell Biology. 4th edition. New York: W. H. Freeman; 2000. Section 19.4, Cilia and Flagella: Structure and Movement. Available from: https://www.ncbi.nlm.nih.gov/books/NBK21698/ 8. Han, KL., Lee, HJ., Shin, M.H. et al. Parasitol Res (2004) 94: 53. doi:10.1007/s00436-004-1158-9 9. RÉVEILLER FL, SUH S, SULLIVAN K, CABANES P, MARCIANO-CABRAL F. Isolation of a unique membrane protein from naegleria fowleri. J Eukaryot Microbiol. 2001;48(6):676-682. doi: 10.1111/j.1550-7408.2001.tb00208.x. 10. Song, KJ., Song, KH., Kim, JH. et al. Parasitol Res (2008) 103: 313. doi:10.1007/s00436-008-0972-x 11. Cope JR, Ali IK. Primary amebic meningoencephalitis: What have we learned in the last 5 years? Curr Infect Dis Rep. 2016;18(10):31-016-0539-4. doi: 10.1007/s11908-016-0539-4 [doi]. 12. Baig AM, Khan NA. Tackling infection owing to brain-eating amoeba. Acta Trop. 2015;142:86-88. doi: 10.1016/j.actatropica.2014.11.004 [doi]. 13. Pugh JJ, Levy RA. Naegleria fowleri: Diagnosis, pathophysiology of brain inflammation, and antimicrobial treatments. ACS Chem Neurosci. 2016;7(9):1178-1179. doi: 10.1021/acschemneuro.6b00232 [doi]. 14. Heggie TW, KÃ ¼pper T. Surviving naegleria fowleri infections: A successful case report and novel therapeutic approach. Travel Medicine and Infectious Disease. . doi: http://dx.doi.org/10.1016/j.tmaid.2016.12.005. 15. Baig AM, Khan NA. Novel chemotherapeutic strategies in the management of primary amoebic meningoencephalitis due to naegleria fowleri. CNS Neuroscience Therapeutics. 2014;20(3):289-290. doi: 10.1111/cns.12225. 16. Jamieson A. Effect of clotrimazole on naegleria fowleri. J Clin Pathol. 1975;28(6):446-449. 17. Siddiqui R, Khan NA. Primary amoebic meningoencephalitis caused by naegleria fowleri: An old enemy presenting new challenges. PLoS Negl Trop Dis. 2014;8(8):e3017. doi: 10.1371/journal.pntd.0003017 [doi]. 18. Miller HC, Morgan MJ, Wylie JT, et al. Elimination of naegleria fowleri from bulk water and biofilm in an operational drinking water distribution system. Water Res. 2016;110:15-26. doi: S0043-1354(16)30912-5 [pii]. 19. Dawson AH, Buckley NA. Digoxin. Medicine. 2016;44(3):158-159. doi: http://dx.doi.org.proxy.campbell.edu/10.1016/j.mpmed.2015.12.006. 20. Procyclidine. Drugs.com Know more. Be sure Web site. https://www.drugs.com/cdi/procyclidine.htm. Updated 2017. Accessed 5/25/17, 2017. [1] Naegleria fowleri- primary amebic meningoencephalitis (PAM) amebic encephalitis. Centers for Disease Control and Prevention Web site. https://www.cdc.gov/parasites/naegleria/pathogen.html#history. Updated December 2015. Accessed January, 2017

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QUES 1: â€Å"Good communication is key to success of any organization.† Justify your statement keeping in view the communication system followed by a bank. Communication is key for success for any organisation . Directing abilities of manager mainly depend upon his communication skills. That is why organization always emphasis on improving communication skills of manager as well as employees. Therefore communication can be defined as, â€Å" the process of exchange of information between two or more persons to reach a common understanding.†Communication is important and pervasive of all managerial activities . communication involves hearing which can’t be said. Communication is what listener do.It is the most important in leading any organization is crafting a strategic vision that achieves your organization’s goals and enhances its effectiveness. Turning this aspiration into a reality means creating and sustaining a unifying sense of purpose on the part of all people within your organization and communicating this vision to your outside audiences.Without effective communication, a message can turn to error, misunderstanding and hence it is interpreted wrongly.It is a process where we can accurately and clearly convey or thoughts and objectives.Communication is successful when both the sender and receiver understand the same information.Communication of ideas establishes a common ground of understanding. Ince the management is concerned with getting the work through others, it implies the manager must communicate with other people. To take decision communication is required.Communication is an exchange of facts , ideas and viewpoints which brings about commonnwss of interest , purpose and efforts.Communication is a sum of all things one p... ...hile conveying message to others , it is better to know the interests and needs of the people with whom you are communicating. 6. Ensure proper feedback- The communicator may ensure the success of communication by asking questions regarding the message conveyed. The receiver or communication may also be encouraged to respond to communication 7. Communicate for present as well as future- Generally , communication is needed to meet the existing commitment, to maintain consistency , the communicaton should aim at future goals of the enterprise also. 8. Follow up communications –There should be regular follow up and review on the instructions given to subordinates. 9. Be a good listener- Manager should be a good listener. Patient and attentive listening solves half of problems. Managers should also give indications of their interest in listening to their subordinates.